Auditable Cognitive Infrastructure for Neurodegenerative Disease Research
Auditable cognitive infrastructure for neurodegenerative disorders integrating genetics, proteomics, and neuroimaging with peer-reviewed methodology. Supports comprehensive evidence structuring across 22 neurodegenerative diseases with validated reproducibility.
Validation Studies
Results reported in our research manuscripts. They describe research cohorts and do not establish clinical performance.
Methodological Rigor & Reproducibility
Validated Tridimensional Analysis Framework
Peer-reviewed methodology analyzing neurodegenerative diseases across three fundamental biological axes. Each axis represents a distinct level of pathophysiological organization with validated biomarker correlations and clinical significance.
Axis 1: Etiological Factors
Comprehensive genetic risk assessment including pathogenic variants, polygenic risk scores, and environmental modifiers.
Clinical Examples: APOE ε4 dosage, LRRK2 G2019S, C9orf72 expansions, MAPT mutations, HTT CAG repeats
Axis 2: Molecular Biomarkers
Multi-omics integration of CSF, plasma, and tissue biomarkers.
Clinical Examples: Aβ42/40 ratio, p-tau181/217, α-synuclein RT-QuIC, TDP-43, neurofilament light
Axis 3: Neuroimaging & Clinical Phenotype
Quantitative neuroimaging analysis and standardized clinical assessments.
Clinical Examples: Hippocampal volumetry, cortical thickness, white matter integrity, amyloid PET SUVR
Clinical Research Applications
Designed for clinical research environments and pharmaceutical development. Supports biomarker discovery, drug target validation and clinical trial design research.
Biomarker Discovery
- • Multi-omics pathway analysis
- • Cross-disease biomarker validation
- • Longitudinal progression markers
- • Treatment response indicators
Clinical Trial Support
- • Patient stratification algorithms
- • Endpoint optimization
- • Power calculation support
Drug Development
- • Target validation studies
- • Mechanism of action analysis
- • Safety biomarker monitoring
- • Companion diagnostic development
Comprehensive Disease Coverage for Clinical Research
The validated tridimensional framework supports 22 major neurodegenerative diseases with disease-specific biomarker profiles, genetic thresholds, and clinical criteria. Designed for differential diagnosis research and clinical trial applications.
Clinical Research Workflow
Data Input
Tabular (CSV) genetic, biomarker, imaging and clinical data
Analysis
Validated algorithms, statistical significance testing, multiple comparison correction
Validation
Cross-validation, bootstrap confidence intervals, sensitivity analysis
Reporting
Statistical documentation of each analysis
Analysis Workflow Guidance
Our workflow guidance helps researchers choose an analysis path based on study design and data availability.
Study Design
Observational, interventional, or biomarker validation study?
Data Modalities
What data types are available? Genetics, biomarkers, imaging?
Intelligent Routing: Automatic selection of optimal analysis pathway
Advance Neurodegenerative Disease Research with Validated Methods
Join leading research institutions and pharmaceutical companies using Neurodiagnoses for biomarker discovery and clinical trial design research.