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Neurodiagnoses: Causal Fusion & Dynamic Prognosis Platform

Our platform uses a Multicomponent Biomarker (MCB) system that operates through a Four-Axis Architecture for continuous trajectory modeling of neurodegeneration.

Axis 0: Context & Intervention

Modifiable factors including treatments and lifestyle. Defines "what-if" scenariosfor treatment-aware predictions.

Examples: Donepezil, Lecanemab, Physical activity, Education

Axis 1: Cause & Etiology

Static risk factors including APOE, GBA1, LRRK2, MAPT and the complete transdiagnostic genetic panel (8 genes).

Genetic panel: APOE, TREM2, GBA1, LRRK2, MAPT, SNCA, PRKN, TBK1

Axis 2: Mechanism & Biomarkers

Molecular mechanisms including ATN+ framework (Aβ, Tau, αSyn, TDP-43) with blood-brain barrier validation.

ATN+ framework: CSF/Plasma Aβ42, pTau, αSyn SAA, TDP-43, NFL, GFAP

Axis 3: Phenotype & Topography

Clinical and topographic manifestations including neuropsychology (MMSE, MoCA), neuroimaging (Midbrain/Pons Ratio, DAT-SPECT), and continuous trajectory simulation.

Modalities: MRI volumetry, PET (Amyloid, Tau, FDG), DAT-SPECT, UPDRS

Final Synthesis: MCB Vector (7 Features)

Our prognostic engine synthesizes these four axes into a Multicomponent Biomarker (MCB) Vector:1 genetic + 2 molecular + 3 topographic + 1 temporal, ensuring transdiagnostic and explainable diagnosis.

🧬 Level 0:

4 Axis-Specific Specialists

👑 Level 1:

Meta-Classifier (Stacked Generalization)

🎯 Coverage:

AD, PD, DLB, PSP, MSA, CBD, FTD

Architecture: 4-Axis Causal Fusion |Variables: 58 transdiagnostic biomarkers & clinical features

Analysis Tools

Choose the right tool for your research needs

Individual Patient Analysis

Case Analyzer

Complete tridimensional analysis (all 3 axes)

Prognosis Analyzer

Risk prediction with partial data

Batch Analysis

Process multiple individual cases at once

Cohort & Research Analysis

Interactive Data Lab NEW

Statistical validation and cohort analysis

Studio

Custom Python/R code for advanced analysis

Workflow Studio

Visual workflow builder (Preview)

🧪 Preview

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🎉 Beta Launch - Free Unlimited Access

All features unlocked during beta phase

Unlimited case analysis

Full access to batch processing

Access to all v15 features

Early access to Studio PoC